Augustin Grisolle (10 February 1811 – 9 February 1869) was a French physician born in Fréjus.
Grisolle was a professor to the Paris faculty of medicine and a member of the Académie de Médecine. He was the author of the two-volume Traité élémentaire et pratique de pathologie interne (1844).
His name is associated with "Grisolle's sign", an obsolete sign once affiliated with smallpox. It involved feeling the presence of papules when the skin is stretched.